
How much does tirzepatide cost per month in 2026?
Brand-name Zepbound costs $299 to $449 a month self-pay at LillyDirect; compounded tirzepatide costs $139 to $399 online (median $237, checked October 15, 2026).
NexLife resource center
Every NexLife guide in one place: what compounded tirzepatide and semaglutide cost, how online programs compare, how to take them safely, and what’s changing with coverage and new drugs. Each guide cites its sources and shows when its prices were checked.
Good places to start: what it costs, which program, and which medication.

Brand-name Zepbound costs $299 to $449 a month self-pay at LillyDirect; compounded tirzepatide costs $139 to $399 online (median $237, checked October 15, 2026).

In our 14-program price index, PreventiveMD is lowest month to month ($139) and Cora on 12 months ($135 a month), checked October 15, 2026.

Of the 10, PreventiveMD is lowest month to month ($119) and Ondra Health on 12 months ($96 a month), checked October 13 and 15, 2026.

In SURMOUNT-5, the head-to-head trial, tirzepatide led to more weight loss than semaglutide: 20.2% versus 13.7% on average over 72 weeks.

Nine programs in our price index offer compounded tirzepatide without a membership, at $139 to $399 month to month (checked October 15, 2026).

NexLife’s prices, as of October 25, 2026: compounded tirzepatide is $139 a month on the 12-month plan or $169 month to month.
What tirzepatide and semaglutide cost per month, by dose and by program, for brand-name and compounded versions.

Brand-name Zepbound costs $299 to $449 a month self-pay at LillyDirect; compounded tirzepatide costs $139 to $399 online (median $237, checked October 15, 2026).

At LillyDirect, Zepbound is $299 a month at 2.5 mg, $399 at 5 mg and $449 from 7.5 mg up (checked October 15, 2026).

Compounded tirzepatide costs $139 to $399 a month online (median $237) and semaglutide $119 to $299 (median $199), month to month, checked October 15, 2026.

Cheapest semaglutide in our 17-program index: PreventiveMD’s $119 month to month, Ondra Health’s $96 a month on 12 months (checked October 13 and 15, 2026).

Cheapest tirzepatide in our 14-program index: PreventiveMD’s $139 month to month, Cora’s $135 a month on 12 months (checked October 15, 2026).

Compounded tirzepatide costs $139 to $399 a month online, month to month and all in, median $237 across 14 programs (checked October 15, 2026).

Compounded semaglutide costs $119 to $299 a month online, all in, with a $199 median across 17 programs (checked October 13 to 18, 2026).

Self-pay, the Wegovy pen costs $349 a month after two $199 fills; compounded semaglutide costs $119 to $299 online (checked October 13–18, 2026).

First-month tirzepatide deals end in month two: Noom goes $149 to $299, Remedy Meds $279 to $399, Shapely $298 to $348 (checked October 15, 2026).

At NovoCare, Wegovy’s 0.25 and 0.5 mg starter fills are $199, then every pen dose up to 2.4 mg is $349 (checked October 15, 2026).

Without insurance, Zepbound costs $299 to $449 per 28-day supply at LillyDirect, by dose, if you refill within 45 days (checked October 14, 2026).

Five of 14 tirzepatide programs in our price index charge under $200 a month, month to month, care included: $139 to $199 (checked October 15, 2026).

Five weight loss injections are sold online by prescription: brand-name Zepbound, Wegovy and Saxenda, and compounded tirzepatide and semaglutide.

Four of 17 semaglutide programs in our GLP-1 price index publish a lower month-one price, then charge $50 to $150 more (checked October 15–18, 2026), and Embody advertises a one-month sale.

Of 26 semaglutide programs we checked on October 13, 2026, 13 cost under $200 a month, all in; 5 of them include coaching or nutrition support and provider check-ins.

Wegovy’s list price drops from $1,349.02 to $675 a month on January 1, 2027; Novo says self-pay prices ($349 pens, $149–$299 pills) aren’t affected.

Tirzepatide already got cheaper: Zepbound fell to $299–$449 a month at LillyDirect in December 2025, with no new cut announced as of October 22, 2026.
Without insurance, without a membership, three months at a time, in installments, or with your HSA or FSA.

Nine programs in our price index offer compounded tirzepatide without a membership, at $139 to $399 month to month (checked October 15, 2026).

Nine of the 14 tirzepatide programs we track charge one price at every dose: $139 to $399 month to month (checked October 15, 2026).

Yes: NexLife accepts Affirm, Klarna and Afterpay at checkout, plus HSA and FSA cards.

Ivím Health adds a $75 monthly membership, Mochi Health $79, and Alloy and Shapely $99, while ten programs charge none (checked October 13–18, 2026).

Without insurance, compounded tirzepatide costs $139 to $399 a month online, and Zepbound costs $299 to $449 at LillyDirect (checked October 15, 2026).

Flat-rate semaglutide means one price at every dose, and 10 of the 17 programs in our price index charge that way (checked October 13–18, 2026).

Yes: an HSA or FSA can pay for compounded tirzepatide prescribed to treat a diagnosed disease, such as obesity, but not for appearance.

Without insurance, compounded semaglutide costs $119 to $299 a month online, and Wegovy $149 to $399 self-pay, pill or pen (checked October 13–18, 2026).

Yes: an HSA or general-purpose health FSA can pay for compounded semaglutide when a physician prescribes it to treat a diagnosed disease, such as obesity.

Without insurance, brand-name GLP-1s cost $149 to $499 a month at makers’ prices with on-time refills (October 2026); compounded ones, not FDA-approved, $119 to $399.

You can appeal, switch to a covered GLP-1 or pay cash: in October 2026, Zepbound runs $299 to $449 a month and Wegovy pens $349.

A 3-month supply of compounded tirzepatide costs $399 to $896 in total at the programs we compared (checked October 21, 2026).

A 3-month supply of compounded semaglutide costs $339 to $837 in our GLP-1 price index (checked October 15, 2026), usually in one charge, not always in one shipment.

Yes: NexLife takes Affirm, Klarna and Afterpay at checkout for compounded semaglutide, $119 a month on the 12-month plan or $139 month to month (prices checked October 25, 2026).
Programs rated side by side, how to check a provider and its pharmacy, and how to switch without starting over.

In our 14-program price index, PreventiveMD is lowest month to month ($139) and Cora on 12 months ($135 a month), checked October 15, 2026.

Of the 10, PreventiveMD is lowest month to month ($119) and Ondra Health on 12 months ($96 a month), checked October 13 and 15, 2026.

To switch without restarting, share your active prescription and current dose: a NexLife provider reviews them and continues your dose when it’s right for you.

There’s no single best tirzepatide compounding pharmacy: a good one is a state-licensed 503A pharmacy that fills only on a prescription and labels each vial.

No tirzepatide provider is right for everyone: three questions on insurance, budget and care match you to one of 11 programs (checked October 15, 2026).

To switch without restarting at 0.25 mg, share your active prescription and dose; a NexLife provider reviews them and can continue your dose.

There’s no single best semaglutide compounding pharmacy: a good one is state-licensed, needs a prescription and labels each vial “semaglutide,” never a salt form.

In our rating of 24 compounded tirzepatide programs, PreventiveMD is lowest month to month ($139), CoreAge Rx on 12 months ($129), checked October 13, 2026.

You need a prescription: licensed telehealth programs sell compounded semaglutide for $119 to $299 a month, and NovoCare Pharmacy sells Wegovy (checked October 13–18, 2026).

Clinics often bill visits and medication separately; online, compounded tirzepatide costs $139 to $399 a month all in, median $237 (checked October 15, 2026).

You need a prescription: licensed telehealth programs sell compounded tirzepatide for $139 to $399 a month, and LillyDirect sells Zepbound (checked October 15, 2026).

In our October 2026 rating of 26 compounded semaglutide programs, PreventiveMD has the lowest month-to-month price: $119 at every dose (checked October 13, 2026).

A legit tirzepatide provider has a licensed prescriber review you first, and a state-licensed pharmacy fill your prescription.
Reviews of each program and its alternatives: prices, what you get, and who each one fits.

Embody’s regular month-to-month price is $349 for compounded tirzepatide, $299 for semaglutide (checked October 15, 2026); Trustpilot rates it 3.8 from 7,276 reviews.

Wellmedr advertises compounded tirzepatide from $89 a month and semaglutide from $49 on a fall sale, but we couldn’t find its regular price (read October 14, 2026).

Mochi Health prices its medication by dose: compounded tirzepatide starts at $169 a month and semaglutide at $139, its $79 monthly membership included (checked October 15, 2026).

Mondae lists compounded tirzepatide at $126 a month and semaglutide $87, at every dose (checked October 25, 2026); Trustpilot showed 3.1 from 97 reviews on October 14, 2026.

Hims prescribes brand-name Zepbound starting at $448 a month and the Wegovy pill starting at $298, its $149 monthly membership included (checked October 15, 2026).

Ro prescribes brand-name Zepbound at $448 to $598 a month and Wegovy at $298 to $548, its $149 monthly membership included (checked October 15, 2026).

MEDVi’s tirzepatide page lists its tirzepatide injection at $166 a month, price-locked, but that page’s FAQ says $199 (checked October 25, 2026).

Ivím Health lists compounded semaglutide from $65 a month and tirzepatide from $116.67, plus a $74.99 monthly program fee (checked October 13, 2026).

Henry Meds charges $297 a month for compounded semaglutide shots and $179 for liraglutide, and lists tirzepatide only as tablets (checked October 22, 2026).

Remedy Meds charges $279 for your first 4 weeks of compounded tirzepatide, then $399 every 4 weeks (checked October 13, 2026): 13 charges and $5,067 in a first year.

Noom’s compounded tirzepatide plan costs $149 for the first 4 weeks, then $299 a month, billed $897 every 12 weeks (checked October 24, 2026).

OrderlyMeds’ 2-month starter is $149 a month for compounded tirzepatide and $74 for semaglutide, then $299 and $149 a month (checked October 24, 2026).

Pomegranate Health lists compounded tirzepatide at “Starts @ $159/mo,” but its pricing page marked it and semaglutide “Sold Out” on October 24, 2026.
Tirzepatide, semaglutide and the brand names (Zepbound, Mounjaro, Wegovy and Ozempic), plus pills and older options.

Zepbound is FDA-approved brand-name tirzepatide, $299 to $449 a month at LillyDirect (checked October 15, 2026).

A tirzepatide pen sets your dose for you; a vial means drawing your dose with a syringe.

Wegovy is FDA-approved brand-name semaglutide, $149 to $399 a month through NovoCare (checked October 15, 2026).

In SURMOUNT-5, the head-to-head trial, tirzepatide led to more weight loss than semaglutide: 20.2% versus 13.7% on average over 72 weeks.

There’s no FDA-approved tirzepatide pill as of October 22, 2026; Foundayo and the Wegovy pill are the FDA-approved GLP-1 pills for weight loss.

Self-pay, Zepbound (FDA-approved tirzepatide for weight loss) is $299–$449/mo with on-time refills; Ozempic, for type 2 diabetes and off-label for weight, $349–$499/mo (October 25, 2026).

Both are Lilly’s tirzepatide: Mounjaro (type 2 diabetes) is $499 a month at LillyDirect, Zepbound (weight, sleep apnea) $299–$449 with on-time refills (October 25, 2026).

Zepbound led to more weight loss in SURMOUNT-5 (2025); at most doses, Wegovy costs $349 monthly self-pay, Zepbound $449 with on-time refills (October 25, 2026).

Both are Novo Nordisk semaglutide: Ozempic is FDA-approved for type 2 diabetes, up to 2 mg; Wegovy for weight, up to 7.2 mg (2026 labels).

Semaglutide is the medicine; Ozempic is one of its three brand names, FDA-approved for type 2 diabetes, not weight loss (labels checked October 25, 2026).

Both are FDA-approved GLP-1 pills, $149 to $299 a month self-pay (October 25, 2026); only the Wegovy pill needs an empty stomach.

Tirzepatide is a weekly shot; Saxenda is a daily one that Novo Nordisk is discontinuing, with its last shipments to wholesalers in late January 2027.

Head to head, Mounjaro (tirzepatide) lowered A1c and weight more than Trulicity (SURPASS J-mono, 2022) and wasn’t worse on heart events (SURPASS-CVOT, 2025).

Zepbound (tirzepatide), a long-term weekly shot, is $299–$449 a month with on-time refills; generic phentermine, a short-term stimulant, is about $12 monthly (October 25, 2026).

Phentermine is a short-term stimulant pill (about $12 a month); semaglutide is a GLP-1 for long-term use (Wegovy pen: $349 self-pay, October 25, 2026).

Generic metformin is $9 a month at the starting dose with a coupon (October 25, 2026); Ozempic, semaglutide for diabetes, was tested alongside it.

Contrave, a twice-daily pill, is $99 a month through its home-delivery program; Wegovy, a weekly semaglutide shot, is $349 self-pay (October 25, 2026).

No head-to-head result yet: as of October 25, 2026, Lilly’s TRIUMPH-5 trial of retatrutide against tirzepatide is listed to run through December 2026.

Zepbound ($299–$449 a month with on-time refills) and the Foundayo and Wegovy pills ($149–$299) are FDA-approved Wegovy alternatives, at self-pay prices checked October 25, 2026.

If Zepbound costs too much, your options in October 2026 are LillyDirect ($299–$449 a month with on-time refills), Wegovy pens ($349) and GLP-1 pills ($149–$299).
What compounded GLP-1s are, whether they’re legal, who qualifies, and how prescriptions work.

Tirzepatide with B12 hasn’t been tested in clinical trials, and compounded versions aren’t FDA-approved or FDA-reviewed for safety, effectiveness or quality; there’s little evidence B12 helps.

Compounded tirzepatide is made by a state-licensed pharmacy for one prescription and isn’t FDA-approved, so the FDA doesn’t review its safety (checked October 22, 2026).

Tirzepatide is a once-weekly weight loss injection that acts on two appetite hormones, GIP and GLP-1.

Yes, compounded tirzepatide is legal when a state-licensed 503A pharmacy prepares it for your prescription and your prescriber documents a significant difference for you.

Compounded semaglutide is semaglutide in a sterile liquid, usually with a preservative, sometimes with vitamin B12.

Compounded semaglutide is prepared by a state-licensed pharmacy for one patient’s prescription; it isn’t FDA-approved.

Yes, tirzepatide needs a prescription, and you can get one online: a licensed provider reviews your history and prescribes only if it’s right for you.

Tirzepatide’s two brand names are Zepbound, for weight loss and sleep apnea, and Mounjaro, for type 2 diabetes; Eli Lilly makes both.

Tirzepatide sold online as “research use only” isn’t made for people: no prescription, no clinician and no pharmacy label.

Sublingual tirzepatide is a compounded tablet that dissolves under the tongue; it isn’t FDA-approved, and how well it’s absorbed hasn’t been through FDA review.

Sublingual semaglutide is a compounded tablet that dissolves under the tongue; it isn’t FDA-approved, and it isn’t Rybelsus or the Wegovy pill, which you swallow.

Yes, every semaglutide needs a prescription, from the Wegovy pen and pill to Ozempic, Rybelsus and compounded semaglutide, and you can get one online.

No: as of October 25, 2026, the FDA hasn’t approved any generic tirzepatide, and Lilly lists its U.S. compound patent through 2036.

No: FDA rules bar approved drugs like tirzepatide from supplements, so no “GLP-1” patch, drop or supplement can legally contain it (checked October 25, 2026).

The BMI requirement for tirzepatide (Zepbound) is 30 or more, or 27 or more with a weight-related condition, per its FDA approval on November 8, 2023.

The 2026 labels say: back up birth control pills for 4 weeks after starting tirzepatide and each dose step; stop semaglutide 2 months before pregnancy.

In December 2024, Zepbound became the first FDA-approved medicine for moderate to severe obstructive sleep apnea in adults with obesity; sleep doctors say keep CPAP.
Injecting, dose charts, side effects, results timelines, food, storage and travel.

Store compounded tirzepatide the way your prescription label says: usually in the fridge at 36°F to 46°F, never frozen.

Units depend on your vial’s strength: in a 30 mg, 3 mL vial (10 mg/mL), 2.5 mg is 25 units on a U-100 syringe.

Keep compounded semaglutide in the fridge at 36°F to 46°F, in its box, unless your label says otherwise, and never let it freeze.

On a standard U-100 insulin syringe, units = your dose in mg ÷ your vial’s strength in mg/mL × 100.

Tirzepatide starts at 2.5 mg and steps up every 4 weeks or more, so the first months are about adjusting.

The most common tirzepatide side effects are nausea, diarrhea, vomiting and constipation, mostly while the dose is rising.

Yes, tirzepatide can cause hair loss, but it’s usually temporary: dermatologists say hair tends to regain its fullness within 6 to 9 months.

Put protein first, eat smaller meals and go easy on large, high-fat meals and alcohol, which can worsen stomach side effects.

Draw your prescribed units into a new U-100 insulin syringe and inject under the skin of your stomach or thigh, changing spots every week.

A tirzepatide maintenance dose is 5 mg, 10 mg or 15 mg once a week, per Zepbound’s label (read October 22, 2026); your provider picks yours.

Restarting tirzepatide depends on how long you stopped: Zepbound’s label, read October 21, 2026, says take a missed dose within 4 days, or skip it.

Restarting semaglutide after 2 or more missed weekly doses means a lower dose, back on the steps, per the Wegovy label (read October 22, 2026).

No official chart converts semaglutide to tirzepatide: the Zepbound label, read October 21, 2026, starts everyone at 2.5 mg a week for 4 weeks.

Compounded semaglutide’s reported side effects mostly look like Wegovy’s, the FDA says, led by nausea: 44% on Wegovy 2.4 mg in trials, versus 16% on placebo.

Semaglutide hair loss is uncommon: 3.3% of people on Wegovy 2.4 mg reported it in trials, versus 1% on placebo (label, read October 25, 2026).

Sometimes: in SURMOUNT-1 (2022) and SURMOUNT-2 (2023), 5% to 7% of people on Zepbound reported fatigue, versus 3% on placebo, its August 2026 label says.

Zepbound’s and Mounjaro’s labels (revised August 2026) don’t forbid alcohol; drinking may worsen nausea and reflux, and can drop blood sugar with insulin or sulfonylureas.

If you took too much, call 911 for an emergency; otherwise call Poison Control at 1-800-222-1222, then your prescriber (number checked October 25, 2026).

Semaglutide results are gradual: in Wegovy’s 68-week trial, people on 2.4 mg lost 14.9% of their weight on average, versus 2.4% on placebo.

A tirzepatide plateau is normal months in, not in your first 4 weeks: Zepbound’s label, read October 21, 2026, calls 2.5 mg a starting dose.

Flying with tirzepatide is allowed: TSA permits medically necessary liquids, gel ice packs and unused syringes with your medicine in carry-ons, declared at screening (checked October 25, 2026).
Insurance and Medicare changes, recalls, and the drugs coming next.

Retatrutide is Eli Lilly’s investigational weekly shot, not FDA-approved as of October 25, 2026, so it has no price per month yet.

Foundayo (orforglipron) is Lilly’s once-daily GLP-1 pill for weight loss, FDA-approved April 1, 2026.

In a February–March 2026 survey, 72% of large employers covering GLP-1s for weight loss said they’ll likely keep coverage in 2027 and 10% likely won’t (Business Group on Health).

Through December 31, 2027, Medicare’s GLP-1 Bridge offers Wegovy, Foundayo or the Zepbound KwikPen for $50 a month to Part D enrollees who qualify; compounded GLP-1s aren’t covered.

For 2027, FEHB and PSHB plans keep covering at least one weight-loss GLP-1 but will require documented behavioral therapy, OPM says; Open Season ends December 14, 2026.

FDA classified three recalls of compounded GLP-1 injections as Class II from October 8 to 13, 2026: Apothecary Pharma, Carolina Infusion and Houston Rx.

Novo Nordisk expects an FDA decision on CagriSema in Q4 2026, and Lilly plans to submit retatrutide in Q1 2027, the companies say.

CagriSema, Novo Nordisk’s weekly cagrilintide-semaglutide shot, isn’t FDA-approved as of October 25, 2026; Novo expects a decision in Q4 2026.
Each state guide covers that state’s Medicaid coverage, its pharmacy and telehealth rules, and online prices.
Shorter reads and updates from the NexLife team.

Online semaglutide pricing in 2026 depends on whether you use brand-name (Wegovy or Ozempic) or, where legally available, compounded semaglutide — plus dose, provider review, pharmacy ful...
Comparamos 10 proveedores de tirzepatida y semaglutida en línea con las mismas seis pruebas.

De los 10 programas de tirzepatida en línea que probamos, PreventiveMD tiene el precio mes a mes más bajo ($139 en cada dosis), consultado el 15 de octubre de 2026.

De los 10 programas de semaglutida en línea que probamos, PreventiveMD tiene el precio mes a mes más bajo ($119 en cada dosis), consultado el 13 de octubre de 2026.
Our prices, whether NexLife is legit, and how we compare programs.

NexLife’s prices, as of October 25, 2026: compounded tirzepatide is $139 a month on the 12-month plan or $169 month to month.

Yes, NexLife is legit: it’s LegitScript-certified, and it’s rated 4.8 out of 5 on Trustpilot from 403 reviews (read October 21, 2026).

Our GLP-1 provider guides compare programs on six tests, and our program ratings score seven, with prices read on each program’s own site, last fully checked October 15, 2026.
Each guide shows when its prices were checked and lists its sources. Programs change their prices often, so the date matters.
Doses, safety and results come from FDA labels and published clinical trials, linked in each guide.
Comparisons put every program, NexLife included, through the same tests, and say at the top that NexLife publishes them. How we compare programs.
Each guide names its medical reviewer and the date it was last updated.
Start with cost and the medication itself: read how much tirzepatide costs per month, then tirzepatide vs. semaglutide. If you’re choosing a program, the provider comparisons rate each one on price, fees and care, and the state guides explain your state’s rules.
Each guide shows the date its prices were checked and links its sources: the providers’ own websites, FDA labels and published clinical trials. Programs change their prices often, so check the date next to any price, and the provider’s own site, before you decide.
No. A state-licensed pharmacy prepares compounded tirzepatide or semaglutide for one person, on a prescription, and the FDA doesn’t approve compounded drugs. Zepbound, Mounjaro, Wegovy and Ozempic are FDA-approved brand-name medicines. Our compounded vs. brand-name guides for tirzepatide and semaglutide compare their prices, FDA status and where to get each.
The NexLife editorial team researches and writes them, and the NexLife clinical team, led by Adam Kennah, MD, reviews them medically. NexLife is a telehealth and care-coordination platform and earns revenue when people join, so each comparison says that at the top and puts every program, NexLife included, through the same tests. Each guide shows its reviewer and the date it was updated.
Compounded tirzepatide at NexLife is $139 a month on the 12-month plan, or $169 month to month. Compounded semaglutide is $119 a month on the 12-month plan, or $139 month to month. The same price at every dose, with no membership fee.
Price Match Guarantee†: paying less with another licensed provider? We match your regular monthly price.
Compounded, not FDA-approved. A licensed provider prescribes it only when it offers a significant difference for you. †Terms apply: see Price Match Guarantee† terms.